When the Doobie Brothers' summer touring schedule ends next weekend, guitarist Patrick Simmons won't be sitting on the couch in front of the television for too long. He and his wife Cris will be participating in the Motorcycle Cannonball Endurance Run 2014.

The ride, which takes place from Sept. 5-21, covers more than 4,100 miles from Daytona, FL to Tacoma, WA. As a way of showcasing vintage motorcycles, all participants have to ride on bikes built before 1936. Simmons will ride a 1929 Harley-Davidson JD, while Cris has a 1934 Harley-Davidson named "Buddy."

“Cris and I are excited, and so ready to head out on the 2014 Motorcycle Cannonball Endurance Run," Patrick said in a press release on the Doobies' website. "We have been working on our bikes for over a year now.”

The duo will be raising money for Stand Up for Cancer in honor of their son, Pat Jr., who successfully battled testicular cancer last year. Cris, who is a member of the National Motorcycle Hall of Fame, participated in the inaugural ride in 2010, finishing 20th out of 45 riders.

On Nov. 4, the Doobie Brothers will release 'Southbound,' a country music tribute to the Doobies that brings five-time Grammy winner Michael McDonald back into fold. Performers include the Zac Brown Band, Blake Shelton and Sara Evans.